Implanted Infected medical devices-curative methods

Medical device market has grown tremendously in past two decades and over 10 million patients receive medical devices, such as catheters and artificial joints every year. Medical devices such as catheters, artificial joints and other “internal” medical devices are prone to infection, which could be a result of formation of biofilms.  These biofilms can be contained in a drug resistant matrix, which make them harder to treat.  Researchers at University of Toronto reported their findings in The Open Access Journal PLoS Pathogens involving therapy that can treat the fungal infections on internal medical devices.

How can researchers treat fungal infection on medical device?

The researchers were able to fight the drug resistance of the fungal infection of pathogens Candida albicans and Aspergillus fumigates by inhibiting the function of Hsp90, a type of protein.  The fungal infect if not cured, often requires removal of the medical device through surgery.

Prof. Leah Cowen, Principal investigator and chair of Canada Research in Microbial Genomics and Infectious Disease at U of T’s Department of Molecular Genetics said “It takes classic antifungals, which were not effective against biofilms, and makes them very...


What data do researchers have for their innovative solution?

An animal study was conducted, which exhibited to completely clear a central venous catheter of a deadly fungal infection by blocking Hsp90 and applying antifungals.

The number of acquired blood stream fungal infections have increased by 200% in last two decades. Researchers have taken a lead by gaining a fundamental understanding of biofilms and their interaction action with drug resistance fungal pathogens.

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